Application NotesPurification of Lipase UL (Rhizopus sp.Q119) using a CIM® DEAE disk monolithic column
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Application NotesOligo dT immobilization on CIMmic CDI-0.1 column
Pre-activated CIMmic™ monolithic columns are cost efficient tools for screening of immobilisation conditions and small scale proof-of-concept testing of custom affinity columns and enzymatic reactor ...
Application NotesFast and semi-automatic optimization of capture step for rAAV purification using CIM® SO3 96-well monolithic plate
First chromatographic step in industrial platform using monoliths is a capture step, where rAAV is selectively bound to strong cation exchanger (SO3) in acidic pH conditions (1,2). In this step majori ...
Application NotesPATfix® mRNA Analytical Methods for Process Development and Production
Robust and precise chromatographic analytical methods are key for efficient development of mRNA production process. Three different analytical methods, which utilize three different column chemistries ...
Application NotesFast purification of the filamentous Potato virus Y using monolithic chromatographic supports
One of the most important plant viruses causing great economical losses in potato production is the filamentous Potato virus Y (PVY); virion size is 740 nm × 11 nm. Preparation of the pure virus susp ...
Application NotesConcentration of Hepatitis A Virus and Caliciviruses Using CIM® QA Disk Monolithic Column
Environmental water is contaminated with human enteric viruses through the discharge of sewage contaminated water. As a consequence, they are present in various environmental water sources: irrigation ...
Application NotesPurification of Ad3 VLPs using CIMac™ QA Analytical Column
Virus like particles (VLPs) are particles that structurally resemble viruses but do not contain any genetic material. They are formed when structural viral proteins spontaneously self-assemble in tran ...
Application NotesRapid Analysis of Adenovirus Type 5 Particles with CIMac™ QA Analytical Column to Support the Development of a High-Titre Manufacturing Platform
Adenoviruses are among the most commonly used vectors for the delivery of genetic material into human cells and as such there is demand for high-titre manufacturing processes. The key to the successfu ...
Application NotesRecovery of pDIKE2 plasmid for Hepatitis C vaccine using CIMmultus™ C4 HLD Advanced Composite Column cGMP
DNA immunization can potentially induce both, humoral and cellular immune responses, and thus comprises an attractive approach for the development of an effective vaccine against HCV. The pIDKE2 plasm ...
Application NotesChromatographic separation of full and empty Adeno-Associated Virus (AAV) particles on CIM® monoliths
Adeno-Associated Virus (AAV)-based vectors of various serotypes are considered to have high potential in human gene therapy and genetic vaccination applications. During manufacturing of AAV vectors un ...