conventional particle-based matrix as a plasmid DNA (pDNA) purification platform. By harnessing the ... differential affinity of pDNA, RNA. Host cell proteins and endotoxin to copper ions in the solution a majority ...
ofpeptide and protein purification. Here, we report a use of SDC to separate plasmid DNA (pDNA ... concentration of AS.SDC was successfully implemented for the enrichment of sc pDNA for plasmid ...
shown to be superior to conventional particle-based column as plasmid DNA (pDNA) purification ... remaining endotoxin were subsequently removed to below detection limit with minimal loss of pDNA using ...
HiP² Plasmid Process Pack™ is a ready-to-use, yet optionally adjustable pDNA purification pack ... , intended to help scientists develop their own pDNA purification process and transfer it to production ...
. In pharmaceutical applications, requirements for purity and efficacy of plasmid DNA (pDNA) as a ... therapeutic product are stringent. The separation of linear, supercoiled (sc) and open-circular (oc) pDNA ...
Chromatography A 1065 (2005) 93-106
The demand of high-purity plasmid DNA (pDNA) for gene-therapy and genetic ... vaccination is still increasing. For the large scale production of pharmaceutical grade plasmids ...
quantity of plasmid DNA (pDNA) throughout the purification process. However, the phenomenon of physical ... entrapment of open circular (OC) isoforms pDNA inside narrow channels of chromatographic support ...
Application of plasmid DNA for gene therapy and vaccination has gained substantial interest in the ... pDNA. Downstream processing has major influence on achieving regulatory demands in pDNA production ...
applicable plasmid DNA (pDNA). To guarantee the supply for the clinical trials and finally for the market new ... pDNA production processes, which meet all regulatory requirements, have to be developed ...
HiP² Plasmid Process Pack™ is a ready-to-use, yet optionally adjustable pDNA purification pack ... , intended to help scientists develop their own pDNA purification process and transfer it to production ...