step Rapid downstream process of AAV with emphasis on chromatographic step of CIMmultus SO3 capture ... Three different ligands full enrichment of AAVWhy orthogonal analytics is the key in downstream development and what are the options ...
polishing is performed with a CIMmultus SO3 cation exchange monolith. The AAV fraction from the ... effective for all AAV serotype tested to date. Cell lysate is directly subjected to column ...
Monoliths are commonly used for separation of empty and full AAV capsids on analytical and ... preparative scale. PrimaS approach for AAV separation employs an ascending pH gradient, which can be ...
empty, partial and heavy AAV capsids The product release criteria of new CIMmultus HR columns, based ... :00 EDT | 16:00 BST | 17:00 CEST Abstract: Separation of empty and full AAV capsids with ...
Removal of empty capsids is a particular goal of AAV purification. Multimodal PrimaT ligand offers ... clearance of contaminating DNA. PrimaT works for different AAV serotypes - for example AAV 2/8 and AAV ...
Presenter: Ingo Nagler Date: June 3, 2020 Biomanufacturing and Cell & Gene Strategy Meetings (Proventa International's online meetings) Click here to listen to BIA's Keynote Presentation ...
serotype independent step to concentrate and purify adeno-associated virus (AAV). Here, we explored ... PXC for adherent and suspension harvests using monolithic chromatographic columns (CIMmultus ...
therapeutically relevant adeno-associated virus (AAV) vectors, used in gene therapy. Beside process- and ... scalability of AAV downstream processing. This study presents the evaluation of highly reproducible (HR ...
commercialized CIMmultus QA monoliths, which have been cited in several AAV downstream processes for ... decade, adenoassociated virus (AAV) vectors have become established as leading gene-delivery ...
For AAV application, we are developing PrimaS column with stricter release criteria for higher ... reproducibility of AAV empty-full separation. Until this product is finalized, PrimaS for AAV is only ...