Sartorius BIA Separations
The CIMac PrimaS Analytical Columns are designed for high-performance chromatography, offering unique selectivity for the analysis and purification of mRNA. Utilizing a multimodal ligand that combines hydrogen bonding with anion exchange properties, these columns provide distinct selectivity compared to traditional anion exchangers. CIMac PrimaS columns are ideal for purifying mRNA from in vitro transcription (IVT) mixtures, efficiently estimating phage concentration, and analyzing impurity profiles, delivering valuable insights with rapid analysis.
Key Features:
- Multimodal ligand combining hydrogen bonding and anion exchange chromatography
- Efficient mRNA purification at ambient temperature with ascending pH gradient
- High selectivity for mRNA, simplifying buffer systems and mitigating hydrolytic effects
- Supports purification and fractionation of single-stranded RNA (ssRNA) by size

