Partners in Progress

Andelyn Biosciences has regularly worked with BIA monolithic chromatography columns in our lab scale and scale up process development programs.  We were delighted to consult with the Sartorius BIA Separations team by providing advice on the development of an AAV harvest capture methodology that was published in the journal Electrophoresis.  We’re excited to see the continuous innovation in chromatography separations for gene therapy applications.”

– Samir Acharya, AD of Process Development, Andelyn Biosciences

Base Facility, Australia

“I was introduced to the PATfix analytical platform at the BASE Facility for the analysis of plasmid DNA and mRNA. The PATfix pDNA analytical platform package was helpful in getting the plasmid analysis running with validated protocols built-in the system. We have also been utilising PATfix for the analysis of IVT mRNA with validated protocols provided by Sartorius BIA Separations. We have been getting consistent and reliable results with high-throughput work processes made possible by the at-line implementation of the PATfix platform. I am happy with the system as it is easy to use, reliable and the support provided by the highly knowledgeable team at Sartorius BIA Separations and Sartorius has been excellent. I am looking forward to continuing working with the PATfix platform and the Sartorius BIA Separations team with their ongoing developments in providing high-quality analytical products.”

– Dae Jong Han, Research Specialist (Analytics), BASE Facility, Australia. Read more here

Teknova

“By leveraging the capabilities of PATfix, I can effectively determine the ratio of empty and full capsids in our samples, thus providing valuable insights into their purity values. The software’s integration functions are designed with user-friendliness in mind, making the analysis process seamless and efficient.”

– Tony Tavares, PhD | Principal Scientist. Teknova

“We have been very happy with the CIM screening plates. They have been incredibly useful for buffer composition screening studies that showed very tight correlation to scaled-up conditions. These are wonderful products that we hope Sartorius will continue to prioritize.”

– Bobby Mills, Senior Development Specialist, Locus Biosciences

“We use BIA Separations Monolith columns for the purification of our mRNA drug substance. The Monolith columns come in multiple sizes to meet our needs from small scale product development work to large scale cGMP manufacturing runs. We have found the Monolith columns to provide high throughput and high purity while being very robust and reliable. In addition, BIA Separations has top notch customer service that never fails to impress.”

– Greg Kubczak, Director of Technical Services and Manufacturing, Arcturus Therapeutics

Working with Sartorius BIA Separations, Pharmaron was able to extend its toolbox of AAV purification solutions, providing multiple-modality options to achieve robust separation of genome-containing (full) from genome-free (empty) viral capsids with high purity and yield for multiple AAV serotypes. During this collaboration, a strong partnership was developed leading to Sartorius BIA separations presenting the work at the second webinar of the Pharmaron Cell and Gene Therapy webinar series. The webinar was entitled “Downstream AAV Production: A Targeted Approach to Optimization”.

Read the News and Case Study

“We are very pleased to be collaborating with BIA Separations / Sartorius in developing and tech-transferring optimized mRNA vaccine manufacturing processes. When time is of the essence, it is crucial to be able to rely on key partners whilst maintaining the highest level of quality in every aspect of our work. We are also very proud that our team was able to produce two kinds of genetic vaccines (DNA and mRNA) and we look forward to expanding our partnership with the BIA Separations’ team on future projects.”

– Hong Thai Pham, CEO, BioNet

Read the News here

“We are especially grateful that BIA Separations shared, and operated, with the same sense of urgency we did to help bring gene therapy to the SMA community. BIA’s experience with AAV purification and its chromatographic technology were important contributions and we look forward to our continued work together.”

– Andy Stober, Senior Vice President of Technical Operations, AveXis

Read the News here

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