The cost of mRNA production is driven by IVT reagents, particularly the co-transcriptional capping ... reagents. Optimization of mRNA yield is therefore crucial for lowering the cost of mRNA production ...
Abstract: Messenger RNA (mRNA) emerged as a powerful therapeutic tool for treatments in gene therapy ... , oncology, and infectious diseases, as recently demonstrated by vaccines against Covid-19. mRNA is ...
purification of mRNA. Its positive charge gives it some anion exchange behavior but hydrogen bonding makes ... exchangers need to be heated into the range of 50–70°C for large mRNA to elute. PrimaS elutes mRNA in a pH ...
CIM® SDVB is a polystyrene divinylbenzene monolith used for reversed phase (RP) purification of large biologics. It is used in purification of nucleic acids for size fractionation. In addition to len ...
Event: Nucleic Acids- cGMP Production of mRNA & pDNA (virtual edition) Date: February 1, 2021 ... Our new Head of Process Development for mRNA and pDNA purification, Rok Sekirnik, presented our ...
Product Manager PATfix platformmRNA-based therapeutics represent a promising new modality for ... optimization, sometimes delayed by weeks and limited by throughput, represents a big bottleneck in mRNA ...
Robust and precise chromatographic analytical methods are key for efficient development of mRNA ... chemistries, are embedded in a ready-to-use PATfix™ mRNA analytical platform to support mRNA process development and product quantification and characterization. ...
mRNA/pDNA presenting our mRNA purification strategy entitled From E. coli to mRNA Drug Substance ... – Development of Analytical and Purification tools for a scalable mRNA production process. ...
In part one of our three-part Meet the Demand for mRNA webinar series, we start our exploration ... into processes, analytics and tools that can help meet the unprecedented demand for mRNA - beginning ...
Part - 2: Break Down the mRNA Bottleneck with Rapid Analytical Strategies In part two of the ... 'Your mRNA process, Simplified' webinar series, we continue to explore how improved processes ...