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3rd Annual Gene Therapy Analytical Development EU

Identifying mRNA production related impurities with a HPLC analytical platform

Speaker: Blaž Bakalar

Abstract:

Optimizing the IVT reaction for a high mRNA yield requires construct-specific considerations. While the IVT reaction might seem simple compared to cell lysates, containing mostly nucleotides and their by-products, effective IVT and subsequent purification process development needs to separate and identify these species, so they can be tracked and removed. The PATfix mRNA analytical platform is specifically designed to tackle this task.

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  • from
    30May2022
    until
    1Jun2022
  • 3rd Annual Gene Therapy Analytical Development EU
  • Location: London, UK