Increasing productivity of IVT reaction using at-line monitoring by HPLC chromatography
Event: Cell and Gene Therapy Insights webinar
Date: April 12, 2022
Presenter: Rok Sekirnik, Head of Process Development, mRNA/pDNA
Key learning points:
- Benefits of implementing HPLC-based analytics in mRNA production workflow
- Principles of monolith chromatography and its use for mRNA analytics and purification
- Principles of IVT reaction and factors affecting rate and yield
- Principles of conversion from batch to fed-batch process