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Increasing productivity of IVT reaction using at-line monitoring by HPLC chromatography

Event: Cell and Gene Therapy Insights webinar
Date: April 12, 2022
Presenter: Rok Sekirnik, Head of Process Development, mRNA/pDNA

Key learning points:

  • Benefits of implementing HPLC-based analytics in mRNA production workflow
  • Principles of monolith chromatography and its use for mRNA analytics and purification
  • Principles of IVT reaction and factors affecting rate and yield
  • Principles of conversion from batch to fed-batch process