CIMmultus PrimaS®

PrimaS

Multimodal chromatography ligand that combines elements of hydrogen bonding with anion exchange chromatography
Offers unique selectivities in many important product areas
Supports purification of single-stranded RNA at ambient temperature and also fractionates ssRNA by size
Bacteriophage purification: Provides superior reduction of endotoxins (up to 7 log removal) compared to strong anion-exchangers (e.g., QA).

For sensitive separations where reproducible chromatography is essential (e.g., AAV empty – full separation), we have developed PrimaS HR column with strict release criteria, ensuring reproducible column performance.

IMPORTANT NOTICE: Column lifetime affected by > 0.1 M NaOH. See updated column stability and cleaning instructions on the Product sheet.

Products

Product name	Catalog no.	Volume	Channel size	Inquiry
CIMmultus PrimaS® - 1 mL (2 μm)	311.5118-2	1 mL	2 μm	CIMmultus PrimaS® - 1 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® - 4 mL (2 μm)	414.5118-2	4 mL	2 μm	CIMmultus PrimaS® - 4 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 8 mL (2 μm)	411.5118-2	8 mL	2 μm	CIMmultus PrimaS® – 8 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 8 mL (2 μm) - cGMP	901.5118-2	8 mL	2 μm	CIMmultus PrimaS® – 8 mL (2 μm) - cGMP quantity Inquiry
CIMmultus PrimaS® – 40 mL (2 μm)	614.5118-2	40 mL	2 μm	CIMmultus PrimaS® – 40 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 40 mL (2 μm) - cGMP	914.5118-2	40 mL	2 μm	CIMmultus PrimaS® – 40 mL (2 μm) - cGMP quantity Inquiry
CIMmultus PrimaS® – 80 mL (2 μm)	611.5118-2	80 mL	2 μm	CIMmultus PrimaS® – 80 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 80 mL (2 μm) - cGMP	911.5118-2	80 mL	2 μm	CIMmultus PrimaS® – 80 mL (2 μm) - cGMP quantity Inquiry
CIMmultus PrimaS® – 400 mL (2 μm)	814.5118-2	400 mL	2 μm	CIMmultus PrimaS® – 400 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 400 mL (2 μm) - cGMP	924.5118-2	400 mL	2 μm	CIMmultus PrimaS® – 400 mL (2 μm) - cGMP quantity Inquiry
CIMmultus PrimaS® – 800 mL (2 μm)	811.5118-2	800 mL	2 μm	CIMmultus PrimaS® – 800 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 800 mL (2 μm) - cGMP	921.5118-2	800 mL	2 μm	CIMmultus PrimaS® – 800 mL (2 μm) - cGMP quantity Inquiry
CIMmultus PrimaS® – 4000 mL (2 μm)	BIA-1014.5118-2	4000 mL	2 μm	CIMmultus PrimaS® – 4000 mL (2 μm) quantity Inquiry
CIMmultus PrimaS® – 4000 mL (2 μm) - cGMP	934.5118-2	4000 mL	2 μm	CIMmultus PrimaS® – 4000 mL (2 μm) - cGMP quantity Inquiry
CIMmultus PrimaS® – 8000 mL (2 μm) - cGMP	931.5118-2	8000 mL	2 μm	CIMmultus PrimaS® – 8000 mL (2 μm) - cGMP quantity Inquiry

Library

All Library Resources

Application & Technical Notes

An Efficient End-to-End AAV8 Platform Process at 50 L Scale

Posters

Optimizing AAV Purification: Comparative Evaluation of Three CIMmultus® Polishing Columns for Enhanced Vector Enrichment and Final Product Purity

Seminars & Webinars

Quality by Design in mRNA Manufacturing: At-Line Monitoring Coupled With DOE for Higher IVT Yield and Efficiency of Purification

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PrimaS

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An Efficient End-to-End AAV8 Platform Process at 50 L Scale

Optimizing AAV Purification: Comparative Evaluation of Three CIMmultus® Polishing Columns for Enhanced Vector Enrichment and Final Product Purity

Quality by Design in mRNA Manufacturing: At-Line Monitoring Coupled With DOE for Higher IVT Yield and Efficiency of Purification

Using Monolith Chromatography to Purify Phages

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