Using Monolith Chromatography to Purify Phages

Ažbe Žnidaršič, Lucija Rebula

Capsid & Tail282. September 2024.

Abstract

Phage purification presents unique challenges due to the complex nature of these viruses and the need for high purity in therapeutic applications. This article delves into the key considerations and innovative techniques used to overcome these challenges, particularly focusing on the removal of impurities like endotoxins.

Traditional methods often fall short, leading to increased costs and reduced efficiency. However, CIMmultus monolithic chromatography offers a promising solution, providing high purity and recovery rates while maintaining phage viability. This approach not only streamlines the purification process but also enhances scalability and cost-effectiveness, making it a valuable tool for both research and industrial applications. Discover how these advancements are shaping the future of phage purification.

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