Production Scale up of SDVB Monolithic Columns for the Purification of mRNA Molecules

Messenger RNA (mRNA) is becoming a major contributor in the fields of gene therapy and vaccines, including those developed in response to the COVID-19 pandemic. Convective Interaction Media (CIM) Styrene divinylbenzene (SDVB) monolithic columns are promising for high resolution purification and separation of mRNA, enabling large-scale production of this molecule. This study demonstrates the ability to prepare homogeneous SDVB monoliths with desired chromatographic properties and economical analytics over the whole size range.