PATfix analytical system is all it takes to accelerate your process development and have continuous at-line production monitoring and robust quality control of nucleic acid drug substances. Designing a correct hardware setup for reproducible analytical separation of large biomolecules is not trivial. Complex IVT mixtures are composed of target molecule (mRNA), process-related impurities (nucleotides, capping reagent, DNA template) and product-related impurities (abortive fragments, dsRNA), all with similar biophysical characteristics. These challenges make the PATfix mRNA platform a preferred analytical solution.
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