CIMmultus OH monolithic columns can be utilized as a chromatographic solution to purify LNPs. This process is used as a direct alternative to existing processes like TFF or dialysis, but is optimized to achieve additional benefits. These columns play a crucial role in refining separation processes, offering high recovery and enhanced particle quality. The study demonstrates that CIMmultus OH columns achieve superior encapsulation efficiency and particle uniformity compared to traditional methods.
These findings highlight the scalability and effectiveness of advanced purification strategies in improving LNP-based drug products, paving the way for innovative solutions in tackling complex healthcare challenges.
