Mastering Monolith Chromatography with DOE Strategies for Lentiviral Vector and Exosome Purification

Speakers:

Maja Leskovec, Head of Process Development Viruses
Luka Bevc, Scientist
Andrej Raspor, Scientist

Join us for an insightful webinar on the latest advancements in monolith chromatography for lentiviral vector and exosome purification. Discover how Design of Experiments (DOE) can streamline your purification processes, ensuring high purity and infectivity.

We’ll explore:

  • The impact of starting salt concentration on lentiviral recovery using CIM QA 0.05 mL Monolithic 96-well Plates.
  • Key factors and conditions for optimizing downstream purification on the QA column.
  • The potential of monoliths in scalable and cost-effective downstream solutions.

Additionally, learn about our innovative approach to optimizing the capture step of extracellular vesicles using the OH column as a substitute for the TFF step. We’ll share insights from our screening study, including:

  • A wide array of binding conditions tested for the OH column.
  • Techniques used to analyze recoveries and purities.
  • How DOE software predicts optimal conditions and the results of our validation run.

What You Will Learn:

  • Discover how Design of Experiments (DOE) can streamline your purification processes
  • Learn about the potential of monoliths in scalable and cost-effective downstream solutions
  • Keep abreast with the latest advancements in monolith chromatography for lentiviral vector and exosome purification

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