In-Process Analytics of AAV Vector Capsid Production

Ivana Petrović Koshmak, Head of Upstream Process Development, Sartorius BIA Separations


In-process analytics of vector capsid production is a critical optimization target in development of AAV-based gene therapy products. In this presentation we introduce a fast at-line HPLC based system that enables differentiation of vector capsid and empty capsid production in transfection mixtures. Case study results demonstrating the effects of different process variables on capsid production and assembly are shown and insights about purification are also discussed.

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