This method guide guides the user on how to start the CIMmultus PrimaS® HR purification for full AAV enrichment.
CIMmultus PrimaS HR is a monolithic chromatographic column. PrimaS HR is a multimodal ligand that combines elements of hydrogen bonding with weak anion exchange chromatography. HR line is a new generation of pre-packed chromatographic monolithic products developed to meet the most demanding separation and purification needs. HR stands for High Reproducibility between batches and different scales. CIMmultus PrimaS HR allows binding of all AAV serotypes and provides advanced removal of product-related impurities, while maintaining high recovery rates.
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