CIMac COOH Monolith for Separation of Monoclonal Antibodies Charge Variants in pH Gradient

Monoclonal antibody (mAb) charge variants have gained considerable attention in the biotechnology industry, due to their potential influence on stability and biological activity of the active pharmaceutical. Cation-exchange chromatography (CEX) is historically one of the typical approaches for mAb purification and characterization, especially charge variant analysis. We have proven the flow independent separation of mAb charge variants using CIMac COOH monolithic column in a pH gradient. In this way, a resolution comparable to classical CEX particulate-based analytical columns was achieved in only 6 min analysis time. Therefore a CIMac COOH column is a perfect choice for fast Process Analytical Control (PAT) of purified mAb samples.

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