Explore our method guide detailing the chromatography-based purification of lipid nanoparticles (LNPs) using CIMmultus® OH monolithic column. Designed for large, shear-sensitive molecules, CIMmultus columns offer fast flow rates and minimal shear stress, ideal for delicate LNP purification. This method efficiently binds LNPs on CIMmultus OH, achieving buffer exchange, ethanol removal, and LNP concentration in a single run. Compared to traditional techniques like TFF and dialysis, it provides higher recoveries, enhanced stability, uniform size distribution, and faster processing, while allowing column reuse to reduce costs.
Sartorius BIA Separations
