Plasmids are an essential element in many advanced therapy medicinal products, which are becoming increasingly important in treating various diseases. The growing demand for plasmid DNA (pDNA) requires efficient, robust, and cost-effective production processes in the biopharmaceutical industry. This application note outlines a downstream purification case study of pDNA using Sartorius technologies and solutions, from cell lysis to final sterile filtration. Comprehensive analytics demonstrate high yield, purity, and integrity of pDNA, achieving >98% supercoiled pDNA and meeting regulatory requirements for key critical quality attributes.
Sartorius BIA Separations
