2024
2024
Join our presentation
Speaker: Andreja Gramc Livk, Head of Process Analytics, Sartorius BIA Separations
Date and Time: Monday, August 19, 2024 | 1:55 PM EDT (Stream: mRNA Development, Analytics and Manufacturing)
Title: Monolithic Columns for mRNA-LNP Therapeutics and Vaccines
Abstract:
Lipid nanoparticles (LNPs) are top non-viral carriers for therapeutics and vaccines due to their encapsulation ability, minimal side effects, and ease of formulation and scaling. Post-formulation, LNPs need processing to meet in vivo application standards. High-resolution analytical tools for monitoring and quality control (QC) are crucial for patient safety and product efficacy.
The presentation will outline diverse applications of monolithic column chromatographic analytics for monitoring critical quality attributes (CQAs) during mRNA LNP production, purification, and release. The monolithic column applications will include:
- Two-dimensional chromatography tool for the analysis of LNPs with no sample pre-treatment. This approach enables determination of critical quality attributes, such as encapsulation efficiency, nucleic acid quantification and size distribution.
- mRNA integrity analysis using ion pair-reverse phase approach.
- Lipid composition analysis.
Using monolithic columns you can streamline your mRNA-LNP optimization and manufacturing, setting optimal critical process parameters.
Stop by our booth (#425)
You are more than welcome to visit our booth to:
- Meet and talk with our team of experts. Gain insights into the latest research and developments in bioprocessing.
- Experience our PATfix analytical system in action. See how this cutting-edge tool can streamline your mRNA-LNP optimization and manufacturing processes.
We can’t wait to connect with you at the Bioprocessing Summit!
About the event
The 16th annual Bioprocessing Summit will bring together thought leaders and pioneers in bioprocess R&D, scale-up, quality, and analytics. Join the event to explore cutting-edge research, exchange insights with industry experts, and chart the course for advancements that will shape the future of bioprocessing.
Location: Boston, MA + virtual
