Bioprocessing Summit

Start:
19
Aug
2024
End:
22
Aug
2024

Location: Boston, MA + virtual

About the event

The 16th annual Bioprocessing Summit will bring together thought leaders and pioneers in bioprocess R&D, scale-up, quality, and analytics. Join the event to explore cutting-edge research, exchange insights with industry experts, and chart the course for advancements that will shape the future of bioprocessing.

Listen to our lecture

Monolithic Columns for mRNA-LNP Therapeutics and Vaccines

Abstract:

Lipid nanoparticles (LNPs) have emerged as the foremost non-viral carriers for therapeutics and vaccines due to their ability of encapsulating various payloads. They show limited adverse effects, are straightforward to formulate and are easier scaled than other viral delivery systems.

Post formulation, LNPs require downstream processing to ensure the formulation is applicable for in vivo applications and adherent to the desired specifications. Therefore, comprehensive, high resolution analytical tools for process monitoring and quality control (QC) of LNPs are critical for ensuring the patients’ safety and product efficacy.

The presentation will outline diverse applications of monolithic column chromatographic analytics for monitoring critical quality attributes (CQAs) during mRNA LNP production, purification, and release. The monolithic column applications will include:

  • Two-dimensional chromatography tool for the analysis of LNPs with no sample pre-treatment. This approach enables determination of critical quality attributes, such as encapsulation efficiency, nucleic acid quantification and size distribution.
  • mRNA integrity analysis using ion pair-reverse phase approach.
  • Lipid composition analysis.

Using monolithic columns you can streamline your mRNA-LNP optimization and manufacturing, setting optimal critical process parameters.

Stop by our booth

Listen to the lecture and visit our booth to explore the first-hand experience of using our PATfix analytical system.

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