Bioprocessing Summit Europe


Location: Barcelona, Spain

Optimization of AAV Downstream Process Development from Harvest to Final Product

Speaker: Rok Žigon, Head of product-application area AAV | Adeno


When it comes to purification of Adeno-associated virus (AAV) achieving a platform process is rather difficult due to the inherent heterogeneity of AAV particles, the variability introduced during upstream processing (USP) and the multitude of AAV serotypes, each with unique properties and therapeutic potentials. The absence of a one-size-fits-all platform process demands a tailored approach to downstream processing (DSP) for each AAV serotype and production condition.
This presentation will cover considerations and examples of case studies for various AAV serotypes for all DSP steps. We will present data from initial lysate clarification and pre-capture options to reduce contaminants, comparison of affinity and ion-exchange capture step and finally   optimization of polishing (full enrichment) step on various monolithic columns, all supported with orthogonal analytics.

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Bioprocessing Summit Europe brings together 750+ upstream, downstream, bioproduction, analytical and formulation professionals to advance the manufacture, quality and control of biological and genetic therapies, and new for 2024, Alternative Proteins such as Cultured Meat. We look forward to seeing you on 19-21 March 2024, with expanded content on downstream processing, smart and sustainable bioproduction, cell and gene therapy and alternative proteins.


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