AAPS National Biotechnology Conference

Listen to our presentation

Speaker: Nejc Pavlin, Process Analytics Development Manager, Sartorius BIA Separations
Time and Date: Monday, May 5, 2025
Title: RNA-LNP Drug Product: Lipid Stability, RNA Impurities and Particle Characterization

Abstract:

In this presentation, we present a robust analytical chromatographic tool, called LNP switcher. It is equipped with two analytical columns of different modalities, independent pumps and multiple detector setup. This configuration enables us to monitor key quality attributes of LNPs production process.

Key Learning points:

• 2D chromatography – all in one assay for LNP analysis
• LNP Encapsulation efficiency determination
• LNP Payload integrity
• LNP Size and size distribution determination

Location: Boston, USA