Our comprehensive portfolio of chromatography consumables is based on monolithic stationary phases, designed for efficient separation, purification, and analysis of large and complex biomolecules. Unlike conventional particle-based resins, monoliths consist of a single, continuous porous structure, enabling unique flow and mass-transfer characteristics that translate into superior performance for modern bioprocessing and analytical applications.
Our monolithic consumables are available in screening, analytical, and preparative formats, allowing seamless method development, scale-up, and routine operation using the same ligand chemistry across all scales and formats. Explore our range of consumables designed to support your bioprocessing tasks:
Monolithic Chromatography: Optimal Ligand Selection
The monolithic chromatography media of our screening products – CIM® Monolithic Well Plates and CIM® Octa, share the same chromatographic properties as our larger, preparative columns CIMmultus®. Allowing you to start with μ-scale and high throughput purification. Transfer your workflow from discovery R&D to development and commercial manufacturing with full GMP compliance.
Here is our quick guide to help you choose the right ligand for your target molecule/application.
| pDNA | RNA | LNP | AAV | LVV | Bacteriophages | Plasma Proteins |
| DEAE (AEX) | Oligo dT (Affinity) | OH (HIC) | SO3 (IEX) | QA (IEX) | QA (IEX) | OH (HIC) |
| C4 HLD (HIC) | Swiper (Multimodal) | QA (IEX) | DEAE (AEX) | PrimaT (Multimodal) | ||
| PrimaS (Multimodal) | QA HR (IEX) | PrimaS (Multimodal) | ||||
| SDVB (Reversed Phase) | PrimaT (Multimodal) | OH (HIC) | ||||
| C4 HLD (HIC) | PrimaS HR (Multimodal) |
Purification
Our Multiuse purification products, like the Preparative Columns CIMmultus® and Product Packs for pDNA, help you separate and purify biomolecules efficiently. These tools are designed to ensure high purity and yield in your processes.
Analytics
We offer Analytical columns CIMac and PATfix® Analytical Standards. These products provide accurate and consistent data, supporting quality control and compliance in your production.
Screening
Our Screening solutions, such as CIM® Monolithic Well Plates, CIM® Octa and CIMmic® Immobilization Screening, are designed to speed up your development processes. They help you quickly screen and optimize your workflows.
Literature
In the Literature section you will find a Book that covers the purification of nucleic acids to support your learning and process development.
