European Pharmaceutical Review, March 2026
Abstract:
The use of monoliths is becoming more prevalent in gene therapy and viral vaccine production. This case study explores the integration of monolith-based anion exchange chromatography (AEX) in lentiviral downstream purification. This approach achieved over 60% transducing unit recovery and a significant reduction in impurities, optimizing NecstGen’s manufacturing platform. The study demonstrates improved recovery and purity of lentiviral vectors, offering a scalable and efficient solution for downstream processing.
