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Ion Exchange

SO3 (sulfate) is a strong cation exchange group, fully charged between pH 2-13. It selectively binds molecules with a predominant positive charge over a working pH range of 2-13. SO3 is a versatile chemistry for various applications in downstream processing. Monolithic SO3 has particularly proven of value for purification and concentration of viruses, VLPs, and large proteins that bind to the ion exchanger on the basis of their positive charge. In mAb production, monolithic SO3 is your tool of choice for sound and efficient removal of aggregates; operate it in flow-through mode during the polishing step.