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Ion Exchange

QA (quaternary amine) is a strong anion exchange group, fully charged between pH 2-13. It selectively binds molecules with a predominant negative charge over a working pH range of 2-13. QA is a versatile chemistry for various applications in capture, intermediate, or polishing steps of downstream processing. Monolithic QA has particularly proven of value for purification and concentration of viruses, VLPs, and large proteins. Its high binding capacity for endotoxins and DNA makes QA your tool of choice for removal of these molecules during the polishing step.

Due to the difference in chemistry of QA (strong anion exchanger) and DEAE (weak anion exchanger), selectivities for a certain molecule are different.