purification of mRNA. Its positive charge gives it some anion exchange behavior but hydrogen bonding makes ... exchangers need to be heated into the range of 50–70°C for large mRNA to elute. PrimaS elutes mRNA in a pH ...
CIM® SDVB is a polystyrene divinylbenzene monolith used for reversed phase (RP) purification of large biologics. It is used in purification of nucleic acids for size fractionation. In addition to len ...
The ligand in CIM® C4 HLD monoliths is a hydrophobic butyl group. RNA binds on the column under hydrophobic conditions. The majority of DNA and short transcripts elute earlier than intact ssRNA, whil ...
distinct from traditional anion exchangers. PrimaS purifies large single-stranded mRNA (ssRNA) under ...
analysis and purification of mRNA. Its positive charge gives it some anion exchange behavior but hydrogen ... anion exchangers need to be heated into the range of 50–70°C for large mRNA to elute. Large mRNA ...
The ligand in CIM® Oligo dT18 is an 18-mer deoxythymidine chain covalently immobilised on the monolith with a carbon linker. RNA with a poly(A) tail binds on the ligand by hybridisation between adeni ...