Platform Purification of Clinical-Quality Bacteriophages published in BioProcess Internationl's Industry Yearbook
Antibiotics are unable to keep pace with infectious diseases, and the use of bacteriophages is a timely solution to that problem. But implementation of bacteriophages involves overcoming some challenges.
Broad-spectrum clinical efficacy will require numerous phages. In turn, cost-effective development of purification procedures will require a platform approach in which one basic process can accommodate all species. That includes the ability to reduce endotoxins to appropriately low concentrations despite the high loads that occur in gram-negative production systems.
Monolithic chromatography media provide a combination of high capacity, fast flow, and low shear stress to enable process simplification and purification efficiency that cannot be reproduced with any other media.
Here you can find BIA Separations' article in BioProcess Internationl's Industry Yearbook, presenting our solution for purification of phages.