Purification of mRNA with CIMmultus PrimaS™

CIMmultus PrimaS purifies large single-stranded mRNA (ssRNA) under aqueous conditions at ambient temperature. It removes dsRNA, DNA, proteins, and endotoxins while fractionating ssRNA in order of increasing size. It can be used for one-step purification of research grade ssRNA or as a high-resolution capture step in a multi-step purification process. It also enables fast high-resolution analytical characterization of in vitro transcription mixtures, partially purified samples, chromatography fractions, and formulated drug substance.