FastFacts: mRNA manufacturing platform using CIMmultus® and CIMac® technology for high recovery of stable mRNA drug substance with rapid HPLC analytics

Published: Cell & Gene Therapy Insights 2021; 7(11), 1409

Date: December 2, 2021

Presenter: Rok Sekirnik, Head Process development for mRNA and pDNA

Watch the video or read the poster to learn:

• Non-affinity chromatography with PrimaS provides purification for IVT processes with co-transcriptional polyadenylation
• The Sartorius mRNA purification toolbox provides a scalable chromatographic solution for commercial manufacturing of mRNA therapeutics
• CIMac analytical HPLC columns can resolve individual IVT reaction components in minutes, resolving the analytical bottleneck in optimization of IVT reaction conditions
• Rapid HPLC analytics can improve in-process and quality control of the mRNA production process