New Resources

This procedure applies to CIMac™ Analytical Columns (0.1 mL), CIM® Disk, CIMmic™, CIM® Tube Monolithic Columns (1 mL and larger) and CIMmultus™ Advanced Composite Columns (1 mL and larger) of aldehyde (AE) activation chemistry.

Attachments

This procedure applies to CIM® Tube Monolithic Columns (1 mL and larger) and CIMmultus™ Advanced Composite Columns (1 mL and larger) of Epoxy (XY) activation chemistry.

Attachments

This procedure applies to CIMac™ Analytical Columns (0.1 mL), CIM® Disk, CIMmic™, CIM® Tube Monolithic Columns (1 mL and larger) and CIMmultus™ Advanced Composite Columns (1 mL and larger) of hydrazide (HDZ) activation chemistry.

Attachments

This procedure applies to CIMac™ Analytical Columns (0.1 mL), CIM® Disk, CIMmic™, CIM® Tube Monolithic Columns (1 mL and larger) and CIMmultus™ Advanced Composite Columns (1 mL and larger) of carboxyimidazole (CDI) activation chemistry.

Attachments

Chromatography is a useful purification method for large biomolecules and virus manufacturing and it is easily scalable to large production volumes. Convective Interaction Media (CIM) monolithic columns constitute of large flow-through channels and consequently have high surface accessibility of binding sites. Preferences of CIM monolithic columns are flow independent performance, resulting in fast separation, concentration, purification, impurities removal, and analytics of biopharmaceuticals.
The aim of the study was to develop Influenza virus purification platform, which can be used for several virus strains. The main objective was to develop a process with as little as possible of intermediate steps, especially omitting Tangential Flow Filtration (TFF) or other sample pre-treatments with high host-cell DNA and protein removal, as well as to achieve high binding capacity of the Influenza virus per mL of monolithic support.

Attachments

F.A.Q.

Yes. Make sure that either the inlet or the outlet of the column is open to prevent excess pressure buildup. Autoclaving monolithic columns for aseptic use is recommended. Prior to disposal, monoliths can also be autoclaved. For specifics, please consult help@biaseparations.com.

Yes.