A comparison of Microparticulate, Membrane, and Monolithic Anion Exchangers for Polishing Applications in The Purification of IgG Monoclonal Antibodies (Courtesy of Pete Gagnon, Validated Biosystems Inc.)

Membrane based anion exchangers are being used increasingly for purification of monoclonal antibodies. The transition from particle-based anion exchangers is driven partly by the convenience of membranes and partly by the cost saving associated with their disposability, however the feature that makes them functionally superior is more effective mass transport.