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Scalable mRNA purification using PrimaS multimodal chromatography

CIM® PrimaS column family combines multimodal anion exchange/hydrogen bonding properties, binding molecules with predominantly negative charge. It is used as capture method for purification of mRNA from IVT (in-vitro transcription) reaction mixture with high binding capacity. High salt wash is used to elute the plasmid and other IVT components from the column without affecting binding of ssRNA.