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Versatility of CIM monoliths for covalent immobilisation of antibodies

The CIM antibody immobilisation platform enables an elegant immobilisation of antibodies, which can be used as immunoaffinity adsorbents in specific diagnostic applications as well as in downstream processes. In this work we show the dependence of the coupling strategy on CIM monolith with the chromatographic efficiency of final immunoaffinity adsorbent. Different activation chemistries (Scheme 1) were tested for the immobilization of two model monoclonal antibodies (mAbs) with subsequent chromatographic characterization of the affinity support.

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